Final answer:
The biggest technological changes include the rise of nanotechnology, the global connectivity afforded by the iPhone, advancements in space exploration, and the groundbreaking discoveries in genetics and medicine.
Step-by-step explanation:
The new millennium has witnessed several technological breakthroughs that have fundamentally altered our daily lives. Nanotechnology and miniaturization have driven the computer industry to integrate technology into myriad devices, making them smaller and more ubiquitous. The advent of the iPhone and portable satellite-based phones has democratised global communication, even in the most remote areas. Space exploration has been redefined with initiatives like the International Space Station and Mars landings, while the revelation of the human genome has triggered unprecedented progress in genetics and medicine. These innovations continue to transform societies and industries around the world.