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Malonaldehyde (MDA) is a termination product of lipid peroxidation. Draw the structure of MDA and provide a rationale for its mutagencity

-*EXAM QUESTION*

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Final answer:

Malonaldehyde (MDA) is a mutagenic molecule that is formed during lipid peroxidation. Its structure consists of a central carbon atom bonded to two aldehyde groups (-CHO) and two hydrogen atoms. MDA's mutagenicity is attributed to its ability to form covalent bonds with DNA.

Step-by-step explanation:

Malonaldehyde (MDA) is a molecule that is derived from the oxidation of fatty acids. It is formed during the process of lipid peroxidation, which occurs when unsaturated fatty acids react with oxygen radicals. MDA is a mutagen, meaning that it has the potential to cause mutations in DNA.

The structure of MDA consists of a central carbon atom bonded to two aldehyde groups (-CHO) and two hydrogen atoms. The molecule is planar with a double bond between the carbon atoms.

The mutagenicity of MDA is due to its ability to react with DNA and form adducts, which are covalent bonds between the MDA molecule and DNA. These adducts can lead to changes in the DNA sequence, potentially causing mutations.

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