Question

The adaptive immune system developed a strategy for monitoring the

proteins synthesized in virtually any cell in the body, thereby preventing pathogens from
'hiding out' by adopting an intracellular lifestyle. To accomplish this, the immune system:

A. Co-opted the ubiquitin-proteasome system used by cell for protein turnover
B. Created a novel pathway using the immunoproteasome for generating peptides
C. Created a novel pathway to express foreign proteins on the cell surface
D. Took advantage of proteolytic enzymes present in endocytic vesicles
E. Engineered an immune-specific ubiquitin molecule for tagging foreign proteins

Answer 1

The adaptive immune system uses the ubiquitin-proteasome system for protein turnover to monitor and present cellular proteins, aiding in the recognition and response to pathogens hiding intracellularly. option e is answer

Step-by-step explanation:

The adaptive immune system developed a strategy for monitoring the proteins synthesized within virtually any cell to detect pathogens that take on an intracellular lifestyle. This strategy involves the cellular machinery of antigen processing and presentation.

The correct answer to the question is A: The immune system co-opted the ubiquitin-proteasome system used by cells for protein turnover. This system tags proteins with ubiquitin, marking them for destruction, and delivers them to the proteasome, a large protein complex that degrades these proteins into peptides.

These peptides are then presented on the cell surface by Major Histocompatibility Complex (MHC) molecules, where they can be recognized by T cells of the adaptive immune system if they are regarded as foreign, instigating an immune response. option e is answer