Question

What activity is encoded by MutY and what does it do?

A. Adenosine glycosylase; creates apurinic site

B. Reverse transcriptase; synthesizes complementary DNA strand using RNA as a template

C. DNA polymerase I; repairs DNA

D. Dam methylase; methylates GATC site

Answer 1

MutY is a DNA glycosylase enzyme that recognizes and removes adenine paired with 8-oxoguanine in DNA. It creates an apurinic site to prevent mutation formation during DNA replication.

Step-by-step explanation:

MutY is a DNA glycosylase enzyme that is responsible for the recognition and removal of adenine paired with MutY is a DNA glycosylase enzyme that is responsible for the recognition and removal of adenine paired with 8-oxoguanine in DNA.

When a guanine base is oxidized to 8-oxoguanine, MutY scans the DNA strand and identifies the mismatched adenine. It then excises the adenine, creating an apurinic site. This repair process prevents the introduction of mutations during DNA replication.