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Which of the following is NOT recruited to the CTD of RNA pol II?"

A) 7methyl-G addition enzymes (capping complex)
B) Chromatin modification complexes
C) Nucleotide excision repair (NER) subunits of TFIIH
D) Proteasome recruitment
E) SCAF spliceosome complex

User Jiluo
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1 Answer

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Final answer:

Proteasome recruitment is not typically associated with RNA polymerase II's C-terminal domain (CTD) during the transcription process, whereas the other entities listed such as capping complex, SCAF spliceosome complex, and chromatin modification complexes are indeed factors that interact with the CTD.

Step-by-step explanation:

The subject in question relates to the recruitment of various factors to the C-terminal domain (CTD) of RNA polymerase II (RNA pol II) during the transcription process. The CTD of RNA pol II plays a crucial role in the processing of pre-mRNA and in recruiting several factors necessary for RNA synthesis and processing. Among the options given, the proteasome recruitment is NOT typically associated with the functions of RNA pol II's CTD during transcription.

The CTD is indeed involved in recruiting the capping complex (7methyl-G addition enzymes) which adds the 5' cap to the nascent RNA, SCAF spliceosome complex for mRNA splicing, and various chromatin modification complexes. TFIIH, mentioned in the nucleotide excision repair (NER) option, is part of the transcription initiation complex and has roles in transcription, but its direct recruitment to the CTD for NER is not the primary function connected to RNA pol II CTD during transcription.

User Micahmckittrick
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