Final answer:
The relationship between the association constant (Ka) and the Free Energy of Reaction (ΔG) is described by the equation: ΔG = -RT ln(Ka). A larger association constant indicates a more stable complex and a smaller free energy change, while a smaller association constant indicates a less stable complex and a greater free energy change.
Step-by-step explanation:
The relationship between the association constant (Ka) and the Free Energy of Reaction (ΔG) is described by the equation: ΔG = -RT ln(Ka). This equation shows that as the association constant increases, the magnitude of the free energy change decreases. In other words, a larger association constant indicates a more stable complex and a smaller free energy change. Similarly, a smaller association constant indicates a less stable complex and a greater free energy change.
For example, if we have two reactions, one with a large association constant and one with a small association constant, the reaction with the larger association constant will have a smaller free energy change, indicating a more stable complex. On the other hand, the reaction with the smaller association constant will have a larger free energy change, indicating a less stable complex.