Final answer:
Non-homologous end-joining (NHEJ) is the repair mechanism that glues both ends of double-stranded breaks together without using sister chromatids. NHEJ is associated with severe combined immunodeficiency.
Step-by-step explanation:
The repair mechanism that repairs double-stranded breaks by simply gluing both ends together without the use of sister chromatids is called non-homologous end-joining (NHEJ).
NHEJ is a DNA repair pathway that rejoins the 'cut' ends of the DNA after a double-stranded break. It involves bringing the DNA strands together and sealing them without the need for a template. This repair mechanism is associated with a type of severe combined immunodeficiency (SCID), a group of rare genetic disorders that lead to a compromised immune system.