Final answer:
Naïve B cells can differentiate into plasma cells upon activation option (d), expressing surface immunoglobulins and playing a key role in the humoral immune response.
Step-by-step explanation:
Naïve B cells are lymphocytes that play a crucial role in the humoral immune response. The correct option for the question 'Naïve B Cells is (d) Can differentiate into plasma cells upon activation. These cells are characterized by expressing surface immunoglobulins (Ig), specifically IgM and occasionally IgD, which serve as receptors for specific antigens.
When naïve B cells encounter an antigen, they are activated and undergo clonal proliferation, and their daughter cells differentiate into plasma cells, which leave the secondary lymphoid organs and settle in the bone marrow.
Plasma cells are specialized to be efficient factories dedicated to the secretion of antibodies and are considered terminally differentiated because they die after their antibody-producing function.