154k views
3 votes
What are the five genes transcribed as a result of TLR-4 recognition?

1 Answer

3 votes

Final answer:

TLR-4 recognition leads to a complex immune response involving the transcription of various genes; while it is not limited to five specific genes, common examples include NF-κB, CXCL8 (IL-8), TNF-α, IL-1β, and IL-6.

Step-by-step explanation:

TLR-4, which stands for Toll-like receptor 4, plays a key role in the innate immune system. When TLR-4 recognizes pathogen-associated molecular patterns (PAMPs), it initiates a signaling cascade that leads to the transcription of various genes involved in the immune response.

However, the specific question regarding the five genes transcribed as a result of TLR-4 recognition is not straightforward as this process can lead to the transcription of a wide variety of genes.

The TLR-4 signaling pathway generally activates genes involved in the production of cytokines, chemokines, and other proteins critical for initiating an effective immune response. This typically includes genes such as NF-κB, which regulates the expression of inflammatory cytokines, chemokines like CXCL8 (also known as IL-8), and other molecules like TNF-α, IL-1β, IL-6.

These genes represent a portion of the broader immune response and provide a glimpse into the complexity of the TLR-4 mediated activation of immune defense mechanisms.

User Mike Sokolov
by
8.6k points
Welcome to QAmmunity.org, where you can ask questions and receive answers from other members of our community.

9.4m questions

12.2m answers

Categories