Question

Primary difference between how B cells and T cells recognize antigen is ________

a. T Cell receptors can bind to antigen only after secretion of the T cell receptor
b. T cell receptors can directly bind to only carbohydrate groups or clusters of amino acids
c. B cells recognize peptide bound to MHC
d. T cells recognize peptide bound to MHC

Answer 1

c. B cells can bind directly to antigens, while T cells recognize antigens that have been processed and presented by MHC molecules.

Step-by-step explanation:

The primary difference between how B cells and T cells recognize antigens is that T cells recognize peptide bound to MHC. B cells can bind directly to antigens in their native form without MHC presentation, functioning as antigen-presenting cells (APCs). T cells, on the other hand, require antigens to be processed and presented to them by MHC molecules on the surface of APCs. B cell receptors (BCRs) can bind to a variety of molecular classes such as proteins, polysaccharides, and lipopolysaccharides, whereas T cell receptors (TCRs) can only interact with antigenic protein epitopes presented within the antigen-binding cleft of MHC I or MHC II.

The primary difference between how B cells and T cells recognize antigen is that B cells recognize peptide bound to MHC, while T cells recognize peptide bound to MHC. B cells function as antigen-presenting cells (APCs) that bind intact antigens, while T cells bind antigens that have been digested and embedded in MHC molecules by APCs. This distinction allows B cells to recognize a wider range of antigens directly, while T cells require the presentation of antigenic peptides on MHC molecules.