Final answer:
DiGeorge's Syndrome involves a deletion on chromosome 22 which can significantly impair the immune system as the thymus may be underdeveloped, leading to susceptibility to opportunistic infections like those seen in SCID. The syndrome also has other health complications, and the choice between answer options would be 'A&C' as both are correct.
Step-by-step explanation:
DiGeorge's Syndrome, also known as 22q11.2 deletion syndrome, is a disorder caused by a deletion on chromosome 22. Specifically, the condition involves a deletion in chromosome 22. This chromosomal defect often results in the poor development of several body systems. Medical problems commonly associated with DiGeorge syndrome include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and behavioral disorders.
One of the significant impacts of DiGeorge Syndrome is on the thymus, an organ crucial for the development of the immune system. Contrary to the statement that the thymus is not affected at all, DiGeorge syndrome often results in a thymus that is either absent or underdeveloped, which in turn impairs the immune system. Consequently, individuals with this syndrome are susceptible to a wide range of opportunistic infections and exhibit a clinical presentation that can resemble Severe Combined Immunodeficiency (SCID), though they are not entirely the same.
A successful treatment for severe immunodeficiencies, like SCID, has been bone marrow transplantation, which involves transferring stem cells from a healthy donor to the recipient to reconstitute an effective immune system. However, this treatment carries risks, as illustrated by the case of David Vetter, also known as the 'Bubble Boy', who developed a fatal complication following a bone marrow transplant.