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Follicular Dendritic cells secrete___ which helps B cells proliferate and differentiate while in the dark zones?

a. CD40 Ligand and IL2
b. CCL21 and CCL19
c. BAFF, IL-15, IL-6, and 8D6
d. CD44, CD38, CD77

User Mellisa
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Final answer:

Follicular Dendritic cells secrete BAFF, IL-15, IL-6, and 8D6, which support B cell proliferation and differentiation in the dark zones of germinal centers.

Step-by-step explanation:

Follicular Dendritic cells (FDCs) are integral to the function of the germinal center, particularly in the dark zone where B cells proliferate and differentiate. The correct answer to what Follicular Dendritic cells secrete to help B cells proliferate and differentiate in the dark zones is c. BAFF, IL-15, IL-6, and 8D6.

These molecules play crucial roles in the survival and maturation of B cells during the immune response. Specifically, BAFF (B cell activating factor) and interleukins such as IL-6 and IL-15 act as survival and proliferation signals for B cells, helping them to mature into antibody-producing plasma cells.

User Batgun
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