Question

Receptor editing refers to _________

a. B cell utilizing its RAG enzymes to produce a new L chain productive rearrangement after recognizing a multivalent self-antigen.
b. B cell utilizing its RAG enzymes to produce a new H chain productive rearrangement after recognizing a multivalent self-antigen.
c. B cell utilizing its TdT enzymes to produce a new H chain productive rearrangement after recognizing a multivalent self-antigen.
d. B cell utilizing TdT enzymes to produce a new L chain productive
rearrangement after recognizing a multivalent self-antigen.

Answer 1

Receptor editing in a. B cells is a process where new light chain rearrangements are generated to avoid self-reactivity using RAG enzymes.

Step-by-step explanation:

Receptor editing refers to a. B cells utilizing their RAG enzymes to produce a new light chain (L chain) productive rearrangement after recognizing a multivalent self-antigen. This process is a form of central tolerance that helps ensure self-reactive B cells do not proceed to become fully mature B cells that might cause autoimmune disease. The correct answer is (a).

As part of the B cell maturation process, the RAG enzymes can reinitiate V-to-J light chain gene rearrangement, allowing for the potential generation of a new antigen receptor that does not react against self-antigens.