Question

Matching: Naive (and activated) B cells have these antibody isotypes on their surface

a. IgM and IgG
b. IgA and IgE
c. IgD and IgM
d. IgG and IgE

Answer 1

Naive B cells have IgM and IgD isotypes on their surface. IgM participates in the initial adaptive immune response, while IgD aids in B cell maturation. The correct answer is c. IgD and IgM.

Step-by-step explanation:

The question asks about the types of antibody isotypes found on the surface of naive (and activated) B cells. Naive B cells have IgM and IgD on their surface. IgM is the primary antibody class found on the surface of naive B cells and is critical for the initial stages of an adaptive immune response. IgD, while present in small amounts, also plays a role in the maturation of B cells into plasma cells upon antigen recognition.

Activated B cells respond in the humoral immune response by producing antibodies. The five different classes of antibodies in humans—IgM, IgD, IgG, IgA, and IgE—each have specific roles in the immune system, contributing to the variety of antibody functions essential for adaptive immune responses. Among these, IgM can form pentamers, enabling the binding to multiple identical antigens, although its antigen-binding is less stable compared to the IgGs produced in large quantities upon re-exposure to the same pathogen.

Answer 2

Naïve and activated B cells have IgD and IgM antibodies on their surface, which are critical for the early stages of the immune response and B cell maturation.

Step-by-step explanation:

The answer to the question regarding the types of antibodies found on the surface of naïve (and activated) B cells is: c. IgD and IgM. Naïve B cells typically have IgM and sometimes IgD antibodies on their surface.

Upon activation, these cells can differentiate into plasma cells which produce and secrete antibodies like IgM, IgG, IgA, and IgE, depending on the required immune response.

IgM and IgD are important for early stages of the immune response, with IgM capable of forming pentamers that bivnd to antigens, and IgD involved in antigen recognition and B cell maturation.