Final answer:
To prevent retinopathy of prematurity in a preterm infant on oxygen therapy, the nurse should regularly use a pulse oximeter to assess oxygen saturation and maintain it within a safe range.
Step-by-step explanation:
In an attempt to prevent retinopathy of prematurity (ROP) in a preterm infant receiving oxygen therapy, the most critical step a nurse can take is to support the neonate's respirations while providing minimal oxygenation. This involves using a pulse oximeter to regularly assess the infant's oxygen saturation levels and ensure they stay within a target range. The aim is to avoid both hypoxia and hyperoxia, as both can contribute to the development of ROP. Covering the neonate's eyes with a shield is not directly related to ROP prevention but may protect from other sources of irritation or damage. The side-lying position doesn’t directly influence ROP risk. Thus, close monitoring through the use of pulse oximetry to guide oxygen therapy is the most relevant approach.