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A nurse takes into consideration that the effect PKU has on the infant's development will depend on:

1. Blood phenylalanine levels in utero

2. Excessive levels of epinephrine at birth

3. Diagnosis within the first 2 days after birth

4. Adherence to a corrective diet instituted early (Nugent 332)
Nugent, Patricia M. Mosby's Review Questions for the NCLEX-RNĀ® Examination, 7th Edition. Mosby, 2011. VitalBook file.

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Final answer:

The development of infants with Phenylketonuria (PKU) largely depends on early diet modifications low in phenylalanine, as unrecognized and untreated high phenylalanine levels can lead to significant brain and central nervous system damage.

Step-by-step explanation:

The effect that Phenylketonuria (PKU) has on an infant's development will depend primarily on the adherence to a corrective diet instituted early.

PKU is an inherited metabolic disorder where the enzyme phenylalanine hydroxylase is deficient, leading to the accumulation of phenylalanine to toxic levels in the body, notably affecting the central nervous system and brain. Symptoms of untreated PKU include delayed neurological development, intellectual disability, and seizures, among other complications.

Pregnant individuals with PKU must manage their phenylalanine levels to prevent fetal exposure, which can lead to developmental issues such as heart defects and microcephaly. Early diagnosis and a strict diet low in phenylalanine are vital to prevent damage and lessen symptoms.

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