Final answer:
If topoisomerase II is rendered non-functional in bacteria, it will lead to an accumulation of positive supercoiling in the DNA, causing DNA strand breakage and inability to replicate properly.
Step-by-step explanation:
If topoisomerase II is rendered non-functional in bacteria, it will lead to an accumulation of positive supercoiling in the DNA. Topoisomerase II is responsible for relieving the tension caused by supercoiling by breaking and rejoining the DNA strands. Without topoisomerase II, the positive supercoiling cannot be resolved, resulting in DNA strand breakage and inability to replicate properly.