Final answer:
Surface complementarity between molecules is the most significant factor in determining whether the interaction will be transient or stable.
Step-by-step explanation:
The most significant factor in determining whether the interaction between macromolecules in the cell will be transient or stable is surface complementarity between molecules. Surface complementarity refers to how well the shapes and structures of the interacting molecules fit together. When the surfaces of the molecules have a high degree of complementarity, they can form stable, highly specific interactions. On the other hand, if the surfaces do not match well, the interaction is more likely to be transient.