Question

What are the steps in which a protein is imported through a nuclear pore?

Answer 1

Protein import through a nuclear pore involves binding of a protein with a nuclear localization signal to a nuclear transport receptor, interaction with nuclear pore fibrils to open the pore, and active transport into the nucleus through ATP hydrolysis.

Step-by-step explanation:

The steps in which a protein is imported through a nuclear pore are as follows:

1. The protein with a nuclear localization signal (NLS) binds to a nuclear transport receptor protein in the cytosol.
2. The complex of the protein and the receptor moves towards a nuclear pore.
3. At the nuclear pore, the complex interacts with nuclear pore fibrils, causing the pore to open.
4. The protein and the receptor cross the double membrane of the nuclear envelope.
5. Inside the nucleus, ATP hydrolysis provides the energy for active transport of the protein into the nucleus against a concentration gradient.