Question

In eukaryotic initiation, one will often see the sequence ACCAUGG as a translational start sequence. This sequence is known as the ________ sequence.

A) Okazaki
B) ETS (eukaryotic translational start)
C) Kozak
D) IRES (internal ribosome entry sequence)
E) CIBS (complex initiation binding sequence)

Answer 1

The sequence ACCAUGG is known as the C) Kozak sequence in eukaryotic initiation, which helps in efficient translation initiation by indicating the correct start codon according to Kozak's rules.

Step-by-step explanation:

The eukaryotic initiation sequence you're referring to, ACCAUGG, is known as the C) Kozak sequence.

This sequence aids in the recognition of the start codon during the initiation of translation in eukaryotic cells.

Unlike prokaryotes that utilize the Shine-Dalgarno sequence, eukaryotes follow Kozak's rules, which suggest that particular nucleotides surrounding the AUG start codon must be present for efficient translation initiation.

The consensus sequence according to Kozak is 5'-gccRccAUGG-3', where 'R' denotes a purine (A or G). The closer this sequence is to the consensus, the higher the efficiency of translation.