Question

Which of the following requires eIFs for initiation?

A) prokaryotic translation
B) chaperonin activity
C) eukaryotic translation
D) eukaryotic transcription
E) post-translational modification

Answer 1

In eukaryotic translation, initiation requires eIFs. eIF-2 is the first protein to bind to the RNA and initiate translation. If eIF-2 is phosphorylated, it impairs the formation of the initiation complex.

Step-by-step explanation:

In eukaryotic translation, the process of initiation requires eIFs (eukaryotic initiation factors).

eIF-2 is the first protein to bind to the RNA and initiate translation. It binds to the high-energy molecule guanosine triphosphate (GTP) and forms an initiation complex with the small 40S ribosomal subunit and the initiator tRNA.

If eIF-2 is phosphorylated, it undergoes a conformational change and cannot bind to GTP, impairing the formation of the initiation complex and impeding translation.