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_____ is the vascular addressin found on endothelial cells of intestinal mucosa that binds to integrins of gut-homing effector lymphocytes.

a. CCL25
b. C-cadherin
c. NOD1
d. MAdCAM-1
e. CXCL13

1 Answer

5 votes

Final answer:

MAdCAM-1 is the vascular addressin on intestinal mucosal endothelial cells that binds integrins on gut-homing effector lymphocytes, helping with immune surveillance in the gut. The correct option is d.

Step-by-step explanation:

The vascular addressin found on endothelial cells of intestinal mucosa that binds to integrins of gut-homing effector lymphocytes is MAdCAM-1. This molecule is essential for the adhesion of lymphocytes to the endothelium and for their subsequent trafficking to the intestinal mucosa, a process critical for proper immune surveillance and response in the gut.

MAdCAM-1 is particularly important in the context of Mucosa-Associated Lymphoid Tissue (MALT), where it facilitates the immune system's interaction with antigens presented in the gut.

Hence, Option d is correct.

User Adam Ryczkowski
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