Final answer:
Option A). The nurse's priority to prevent wound infection in a client with a major burn injury is to use sterile dressings for wound care.
Step-by-step explanation:
When caring for a client with a significant burn injury, the nurse's top priority should be to avoid wound infection by using sterile dressings. By forming a barrier between the wound and dangerous bacteria, sterile dressings help lower the chance of infection. Although it might be required, topical antibiotic application is not the nurse's top priority. Although keeping up regular hand washing and putting the patient in protective isolation are crucial infection control practices for healthcare environments generally, they might not be the nurse's top priority in this particular situation to prevent wound infection.