Final answer:
The nuclear domain of intracellular receptors binds to responsive elements in the nucleus.
Step-by-step explanation:
The domain of intracellular receptors that binds to responsive elements in the nucleus is known as the zinc-finger domain. This domain is crucial for the DNA binding to particular response elements, which allows for the activation of gene transcription. The intracellular nuclear receptors, such as those for thyroid hormones, are part of a broader family of nuclear receptors that also includes steroid hormone receptors.
These receptors act as hormone-activated transcription factors and function by modulating gene expression. Upon hormone binding, these receptors undergo a conformational change that exposes their DNA-binding site, enabling them to move into the nucleus and initiate gene transcription by binding to hormone response elements (HREs).