Question

Which of the following is capable of undergoing successive rearrangements to prevent the formation of autoreactive lymphocyte receptors?

A. IgL?
B. TCRa
C. IgHµ
D. Both A and B
E. All of the above

Answer 1

The components capable of undergoing successive rearrangements to prevent the formation of autoreactive lymphocyte receptors are both IgL (Immunoglobulin Light chain) and TCRa (T cell Receptor alpha chain), which is answer D. Both A and B.

Step-by-step explanation:

The question asks which components can undergo successive rearrangements to prevent the formation of autoreactive lymphocyte receptors. The correct answer is D. Both A and B, meaning both IgL (Immunoglobulin Light chain) and TCRa (T cell receptor alpha chain). Successive rearrangements in the B and T cell receptors occur during lymphocyte development to create a vast array of receptors that can recognize a plethora of antigens yet avoid harmful autoreactivity.

For B cells, this involves rearrangements of V (Variable), D (Diversity), and J (Joining) gene segments for the IgHµ (heavy chain) and V-J for the IgL. Similarly, TCR diversity is achieved through the rearrangement of V, D, and J segments for the TCR ß chain and V-J for the TCRa chain. This process helps in the prevention of the development of lymphocytes that are reactive against the body's own tissues.