Question

In which cells are the IgL loci rearranged by RAG-1/2?

A. Developing T cells
B. Developing B cells
C. Developing neutrophils
D. Developing monocytes
E. None of the above

Answer 1

Option (B), The IgL loci are rearranged by RAG-1/2 in developing B cells, a key process for the adaptive immune response, allowing the production of a diverse range of antibodies.

Step-by-step explanation:

The IgL loci are rearranged by RAG-1/2 in developing B cells. This rearrangement is part of the process where B cells generate a diverse repertoire of antibody molecules necessary for the adaptive immune response. B cells are produced in the red bone marrow and mature there as well, unlike T cells which migrate to the thymus to mature.

The rearrangement of the IgL loci, which includes multiple variable (V), diversity (D), and joining (J) regions linked to a constant (C) region, allows B cells to produce a wide variety of antibodies to respond to different antigens. Following activation by an antigen, B cells can differentiate into plasma cells, which secrete antibodies specific to that antigen.