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Which of the following components that are essential for rearrangement of the IgH and IgL loci are not utilized in rearrangement of the TCR loci?

A. RAG-1/2
B. Artemis
C. TdT
D. RSS sequences with spacers of 12 bp and 23 bp
E. All of the above are essential for rearrangement of the TCR loci

User Ayesha
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1 Answer

5 votes

Final answer:

All of the components listed, including RAG-1/2, Artemis, TdT, and RSS sequences with 12 bp and 23 bp spacers, are used in the rearrangement of both the IgH/IgL and TCR loci. Thus, none of these components are exclusive to the IgH and IgL loci rearrangements.

Step-by-step explanation:

The components that are essential for rearrangement of the immunoglobulin heavy (IgH) and light (IgL) loci but not utilized in the rearrangement of the T-cell receptor (TCR) loci are RAG-1/2, Artemis, TdT, and RSS sequences with spacers of 12 bp and 23 bp.

However, answer option E, stating that all components listed are essential for the rearrangement of the TCR loci, is incorrect. The TCR gene rearrangement also makes use of RAG-1/2, Artemis, TdT, and RSS sequences with spacers of 12 and 23 bp.

Therefore, none of the components listed in the options is exclusive to IgH and IgL loci rearrangement as they are also involved in TCR loci rearrangement. The process of VDJ recombination, which is facilitated by these components, generates the diversity of antigen receptors that are critical for the immune response.

User Pragalathan  M
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