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What introduces a transient hairpin that links the two strands in the V(D)J coding regions?

A. TdT
B. Artemis
C. RAG-1/2
D. XRCC4 with DNA ligase IV
E. Ku 70 and Ku 80

1 Answer

1 vote

Final answer:

The introduction of a transient hairpin that links the two strands in the V(D)J coding regions is mediated by the RAG-1/2 proteins.

Step-by-step explanation:

The introduction of a transient hairpin that links the two strands in the V(D)J coding regions is mediated by the RAG-1/2 proteins. The RAG-1/2 proteins, also known as recombination activating gene proteins, are responsible for the rearrangement of the variable (V), diversity (D), and joining (J) segments in the genes that code for immunoglobulins or T-cell receptors.

These proteins recognize and bind to specific recombination signal sequences (RSS) flanking the V, D, and J segments, and catalyze the formation of DNA double-strand breaks, resulting in the formation of hairpin structures that join the segments together during the process of V(D)J recombination.

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