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Centroblasts use the DNA-modifying enzyme AID for what processes?

a. Isotype switching & Somatic recombination
b. Somatic recombination & Somatic hypermutation
c. Isotype switching & Somatic hypermutation
d. Isotype switching, Somatic recombination, & Somatic hypermutation

User LeeR
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Final answer:

Centroblasts utilize AID for somatic hypermutation and isotype switching, both of which are critical for antibody diversification and effective immune responses.

Step-by-step explanation:

Centroblasts utilize the DNA-modifying enzyme Activation-Induced Cytidine Deaminase (AID) primarily for two key processes: somatic hypermutation (SHM) and class switch recombination (CSR), which is also known as isotype switching. These processes are critical for the diversification of the B-cell receptor (BCR) repertoire and the production of effective antibody responses. Somatic hypermutation introduces point mutations into the variable regions of the immunoglobulin genes, increasing the diversity and specificity of antibodies. Class switch recombination, on the other hand, involves recombination between switch regions upstream of immunoglobulin heavy chain constant regions, allowing a B cell to produce antibodies with different effector functions.

Based on the provided options and understanding of B cell maturation and antibody production, the correct answer is c. Isotype switching & Somatic hypermutation.

User Waldyrious
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