Question

Rearrangement (somatic recombination) of the light chain of the B-cell receptor includes:

a. RAG complex activity
b. MHC restriction
c. The V and J gene segments
d. A & C
e. B & C

Answer 1

The rearrangement (somatic recombination) of the light chain of the B-cell receptor includes the V and J gene segments. This process involves the random excision of these segments and splicing them together, resulting in B cells having a unique variable region.

Step-by-step explanation:

The rearrangement (somatic recombination) of the light chain of the B-cell receptor includes the V and J gene segments. An enzyme called DNA recombinase randomly excises most of these segments and splices one V segment to one J segment. This rearrangement process results in each B cell having a unique variable region capable of binding a different antigen.