Final answer:
The false statement regarding follicular dendritic cells (FDCs) is that they utilize MHC class II to present antigen to B cells, which they do not. Instead, they hold intact antigens for B cells, have complement receptors, and an extensive surface area. Therefore, correct option is e.
Step-by-step explanation:
The question relates to follicular dendritic cells (FDCs) and their characteristics within the immune system. Specifically, the options are assessing various attributes of FDCs in the context of their receptor expression and antigen presentation capabilities.
Top of Form Follicular dendritic cells (FDCs) are immune cells found in the germinal centers of lymph nodes. The false statement among the given options is that FDCs utilize MHC class II to present antigen to B cells.
This is incorrect because FDCs do not present antigens via MHC class II molecules; instead, they present intact antigens to B cells for the purpose of B cell activation and affinity maturation.
MHC class II molecules are typically expressed by professional antigen-presenting cells like dendritic cells, macrophages, and B cells. Therefore, the answer is e. A & C.
For further clarity:
- FDCs do have complement receptors, which help in trapping immune complexes.
- They serve as a reservoir of intact antigens, which is crucial for the selection of high-affinity B cells.
- They indeed have an extensive surface area, which is beneficial for their role in antigen presentation to B cells.