Question

During somatic recombination, the diversity established as a result of the rearranged genes would be expected to reside within the CDRs for both the H-chain and L-chain variable regions.

a. True
b. False

Answer 1

B. False. The diversity established as a result of somatic recombination is expected to reside within the CDRs of both the H-chain and L-chain variable regions.

Step-by-step explanation:

B. False

Somatic recombination is the process by which diverse antibodies are generated in B cells.

In this process, V (Variable), D (Diversity), and J (Joining) gene segments in the light and heavy chains of the immunoglobulin genes rearrange to create unique variable regions.

These variable regions, also known as complementarity determining regions (CDRs), are responsible for binding to antigens.

Therefore, the diversity established as a result of somatic recombination is expected to reside within the CDRs of both the H-chain and L-chain variable regions.

For example, in B cells, the V, D, and J segments combine to generate diverse heavy chains containing CDRs, while the V and J segments combine to generate diverse light chains containing CDRs as well.