Final answer:
T-cells undergo development in primary lymphoid tissue, specifically the thymus, with Notch-1 signaling playing a crucial role in their maturation through processes such as positive and negative selection. The correct answer to the student's question is d.
Step-by-step explanation:
The correct answer to the student's question is d. T-cells ; development ; primary lymphoid tissue. T-cells, or T lymphocytes, undergo their development within primary lymphoid tissue, which is specifically the thymus gland. This process is critical for establishing a functional and diverse T-cell repertoire capable of adapting to the myriad of pathogens the body may encounter.
Notch-1 signaling is an essential pathway involved in the maturation of T-cells within the thymus. This includes processes such as positive selection, which ensures that the developing T-cells can recognize self-MHC molecules, and negative selection, which eliminates T-cells that are strongly reactive to self-antigens to prevent autoimmunity.