Question

During the maturation of both B cells and T cells, which of the following enzymes would you expect to be working?

a. RAG-1 & RAG-2
b. AID
c. TdT
d. A & B
e. A & C

Answer 1

The maturation of B and T cells involves the activity of RAG-1 & RAG-2 and TdT, enzymes that participate in the creation of diverse antigen receptors through recombination and nucleotide addition.

Step-by-step explanation:

The correct answer to the question is e. A & C, which refers to the enzymes RAG-1 & RAG-2 and TdT (Terminal deoxynucleotidyl Transferase). These enzymes are critical for the development and maturation of B cells and T cells.

RAG-1 & RAG-2 are enzymes involved in the recombination process that generates the diverse array of antigen receptors necessary for the immune system to recognize a vast variety of antigens. This process, known as V(D)J recombination, occurs in both B cells and T cells and is essential for creating the diversity of the antigen-binding sites.

Terminal deoxynucleotidyl Transferase (TdT) is an enzyme that adds nucleotides at random to the V(D)J junctions during the recombination process, contributing further to the diversity of the antigen receptors, which is crucial for the adaptive immune system's ability to recognize and respond to a wide range of pathogens.