Question

Which of the following statements is true about γδ T-cells?

a. They utilize RAG-1 and RAG-2 during maturation.
b. During somatic recombination, the V region genes undergo DNA changes.
c. The δ gene segment can incorporate two D segments during maturation.
d. pTα is not involved during their development.
e. All of the statements above are true.

Answer 1

γδ T-cells are a subset of T-cells with a unique type of T-cell receptor. They undergo genetic rearrangement like αβ T-cells but do not involve RAG-1, RAG-2, or pTα in their development. The correct statement is that during somatic recombination, the V region genes undergo DNA changes.

Step-by-step explanation:

γδ T-cells are a subset of T-cells that express a specific type of T-cell receptor (TCR) called γδ TCR. These cells play a unique role in the immune response as they can recognize and respond to antigens in a different way compared to αβ T-cells, which have a different type of TCR.

As for the statements:

• a. They do not utilize RAG-1 and RAG-2 during maturation. The rearrangement of their TCR genes does not involve these enzymes.
• b. During somatic recombination, the V region genes undergo DNA changes is true. γδ T-cells, like αβ T-cells, undergo genetic rearrangement of V, D, and J gene segments to create diverse TCRs.
• c. The δ gene segment can incorporate two D segments during maturation is false. The δ gene segment does not have a D segment.
• d. pTα is not involved during their development is true. γδ T-cell development does not require pTα, which is necessary for αβ T-cell development.
• e. Not all of the statements are true, so the correct answer is option b.