Final answer:
The MHC class I molecules, which include HLA-A, HLA-B, and HLA-C, present peptides to B. I; CD8 T cells. These molecules are found on all nucleated cells. On the other hand, MHC class II molecules present to CD4 T cells and are only found on professional antigen-presenting cells such as macrophages, dendritic cells, and B cells.
Step-by-step explanation:
The student is asking about the relationship between major histocompatibility complex (MHC) molecules and T cells.
The correct answer to the question 'Human MHC class __ isotypes, such as HLA-A, HLA-B, and HLA-C, will present peptide to __ T cells.' is b. I ; CD8.
This means that MHC class I molecules present peptides to CD8 T cells.
MHC class I molecules, which include HLA-A, HLA-B, and HLA-C, are found on all nucleated cells and are responsible for presenting peptides (which can be derived from normal self-antigens as well as abnormal or nonself pathogens) to CD8+ T cells.
In contrast, MHC class II molecules are expressed only on professional antigen-presenting cells (APCs) such as macrophages, dendritic cells, and B cells, and bind to CD4 molecules on T cells.