Final answer:
When B cells in the bone marrow bind to self-antigens, they can undergo anergy, receptor editing, and apoptosis, all of which are mechanisms to prevent autoimmunity by enforcing central tolerance.
Step-by-step explanation:
When B cells that bind to self-antigens in the bone marrow undergo negative selection, this can lead to: e. A, B, & C meaning anergy, receptor editing, and apoptosis.
Anergy refers to a state in which B cells become functionally inactivate upon binding to soluble antigens in the bone marrow. Anergy occurs when the B cell becomes unresponsive and fails to produce an immune response. Receptor editing is a process where the B cell modifies its antigen receptor to prevent self-reactivity. Apoptosis is the programmed cell death of the self-reacting B cell to eliminate it from the population.Receptor editing is a process where these B cells attempt to change their receptor specificity to avoid self-reactivity. Lastly, apoptosis is the programmed cell death of B cells that strongly bind to self-antigens, removing the potential for autoimmunity. The elimination of self-reactive B cells is a critical part of achieving central tolerance and preventing the immune system from attacking the body's own tissues.