Final answer:
The proto-oncogene that is highly associated with Burkitt's lymphoma is MYC, which when mutated, can cause the overproduction of B cells leading to tumor development.
Step-by-step explanation:
The proto-oncogene highly associated with the development of Burkitt's lymphoma is MYC.
The proto-oncogene MYC is commonly involved in Burkitt's lymphoma.
Proto-oncogenes serve as positive regulators of the cell cycle, and when they are mutated, they can become oncogenes that contribute to cancer formation by promoting uncontrolled cell growth. The MYC oncogene, in particular, plays a significant role in the pathogenesis of Burkitt's lymphoma. MYC is a transcription factor that, when aberrantly activated, can cause the transformation of normal B cells into malignant cells.
This overexpression of MYC in B cells results in rapid and uncontrolled cell proliferation, leading to the development of tumors. Burkitt's lymphoma is characterized by the presence of these tumors, which can grow significantly and cause symptoms such as swelling of the jaw or abdominal masses. Affected individuals may have difficulty eating or other complications due to the physical presence of these tumors. Understanding the role of MYC is crucial in devising targeted therapies for the treatment and management of Burkitt's lymphoma.