Final answer:
The kidneys are the most important organ for regulating blood composition, performing functions such as waste removal, regulation of pH, blood pressure, solute concentration, erythropoiesis through EPO production, and vitamin D synthesis. Although the liver, spleen, and small intestine have their roles, they do not regulate blood composition as directly as the kidneys do. The final answer to the question is D. Kidneys.
Step-by-step explanation:
Regulation of Blood Composition
The organ that plays the most important role in regulating blood composition is the kidneys. The kidneys maintain homeostasis, which includes the stabilization of the body's internal environment. They carry out vital functions such as removing waste, regulating pH levels, controlling the concentration of solutes in the blood, and final synthesis of active vitamin D. Furthermore, they produce erythropoietin (EPO), which is essential in the production of red blood cells. The liver also plays a significant role in metabolism and detoxification, but the kidneys are primarily responsible for directly maintaining the composition of the blood.
The spleen and the small intestine are involved in blood filtration and nutrient absorption respectively, but these organs do not have the same regulatory functions on blood composition as the kidneys do. The liver's contribution to blood composition includes metabolism, digestion, and detoxification, but when it comes to direct regulation and maintenance, the kidneys are of paramount importance. Therefore, the correct option is D. Kidneys.