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The δ-chain locus is positioned within the γ-chain locus, and is consequently deleted and inactivated during rearrangement of the gene segments.

a. True
b. False

User Gwinn
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1 Answer

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Final answer:

The statement concerning the δ-chain locus being positioned within the γ-chain locus and being deleted during rearrangement is false, as gene rearrangement processes for TCRs are more complex.

Step-by-step explanation:

The statement that the δ-chain locus is positioned within the γ-chain locus, and is consequently deleted and inactivated during rearrangement of the gene segments is false. This question relates to the mechanisms of genetic rearrangement occurring in the immune system's B or T cells, which ensure a diverse antibody or T-cell receptor (TCR) repertoire. Specifically, the δ-chain mentioned is part of the TCR, and the processes involved are a bit different from antibody gene rearrangement.

The rearrangement for TCRs and antibodies ensures that a plethora of unique variable regions are created, which can bind to diverse antigens. However, the δ-chain locus and γ-chain locus are not arranged in such a linear fashion that the deletion of one necessarily leads to the inactivation of the other. In fact, the TCR δ-chain locus and γ-chain locus undergo complex recombination events separate from the antibody light and heavy chains.

User Ramesh Kanjinghat
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