Final answer:
The incorrect statement about macrophages is that they remain in circulation until an infection breaches the first lines of defense.
Step-by-step explanation:
The incorrect statement about macrophages is b. They remain in circulation until an infection breaches the first lines of defense. Macrophages are expected to reside within the tissues and are one of the first effector cells to encounter a newly established infection. They can function in both innate and adaptive immune responses. Therefore, option b is incorrect.