Final answer:
Blood-borne pathogens can cause infectious diseases such as malaria and hepatitis, but sickle cell disease, a genetic noninfectious disease, is not caused by such pathogens.
Step-by-step explanation:
Blood-borne pathogens are responsible for various infectious diseases that are transmitted through contact with infected blood or other body fluids. Commonly recognized diseases caused by blood-borne pathogens include malaria, caused by the protozoan genus Plasmodium and transmitted by mosquitoes, as well as diseases like HIV/AIDS, hepatitis B, and hepatitis C. Such pathogens can enter the bloodstream through contaminated medical equipment, unsanitary piercings, and open wounds. However, not all diseases in the circulatory system are infectious. For example, sickle cell disease is a noninfectious genetic disorder characterized by abnormally shaped red blood cells and is not caused by a pathogen. Therefore, sickle cell disease is the correct answer to the question as it is a non-communicable illness that cannot be contracted through blood-borne pathogens.