Final answer:
The lesion in single eye blindness is most likely to be in the optic nerve before the chiasm.
Step-by-step explanation:
The lesion in single eye blindness is most likely to be in the optic nerve before the chiasm. In the optic pathway, the optic nerve carries visual information from the eye to the optic chiasm. The axons from the medial side of each retina decussate (cross over) at the optic chiasm, so if there is a lesion in one of the optic nerves before the chiasm, it can result in blindness in one eye.