Final answer:
The edge of an enlarged spleen is typically felt about three centimeters below the costal margin during deep inspiration. Its location in the upper-left quadrant of the abdominopelvic cavity is due to its attachment to the stomach and close relation to the diaphragm.
Step-by-step explanation:
The edge of an enlarged spleen is palpable about three centimeters below the costal margin on deep inspiration. The spleen is located in the upper-left quadrant of the abdominopelvic cavity, just inferior to the diaphragm and attached to the stomach via the gastrosplenic ligament.
Its role as a secondary lymphoid organ is crucial, filtering blood, and presenting antigens to lymphocytes within its germinal centers. The spleen is highly vascular and, when enlarged, may be felt upon physical examination, typically indicating an underlying condition requiring medical attention.