Final answer:
Inactive type I nuclear receptors are B. anchored in the cytoplasm by chaperone proteins. Once a ligand binds, they disassociate and move to the nucleus to initiate gene transcription.
Step-by-step explanation:
Inactive type I nuclear receptors are found in the cytoplasm anchored by chaperone proteins such as heat shock proteins (HSP). These receptors bind to hydrophobic ligands that are capable of crossing the plasma membrane. Upon ligand binding, the receptor disassociates from the chaperone protein and the complex translocates to the nucleus. In the nucleus, the hormone-receptor complex binds to a DNA sequence called a hormone response element (HRE), which then initiates the transcription of specific genes. This process ultimately leads to the translation of proteins which mediate changes in cell function, as is the case with steroid and thyroid hormones, and hormones derived from cholesterol.
Inactive type I nuclear receptors are Anchored in the cytoplasm by chaperone proteins.
Internal receptors, also known as intracellular or cytoplasmic receptors, are found in the cytoplasm of target cells and respond to hydrophobic ligand molecules that are able to travel across the plasma membrane. These receptors are usually bound to chaperone proteins in their inactive state. When a hormone binds to the receptor, the receptor dissociates from the chaperone protein and translocates to the nucleus to initiate gene transcription and translation.