Final answer:
Option (B), Endocrine signaling is the form of extracellular signaling that reaches the farthest, as it uses the body's circulatory system to transport signaling molecules over long distances to distant cells.
Step-by-step explanation:
The form of extracellular signaling that reaches the farthest is endocrine signaling. Unlike paracrine, autocrine, synaptic, and contact-dependent signaling, endocrine signaling uses the circulatory system to transport hormones and other signaling molecules over long distances throughout the body.
For example, the secretion of hormones by the pituitary gland is a form of endocrine signaling, showcasing how signals can travel to distant cells and elicit responses.