Question

Membrane anchoring of heterotrimeric G proteins requires post-translational lipid modification of

A. G-alpha and G-beta
B. G-beta and G-gamma
C. G-alpha and G-gamma
D. G-beta
E. G-alpha, G-beta and G-gamma

Answer 1

The post-translational lipid modification required for membrane anchoring of heterotrimeric G proteins involves the modification of G-alpha and G-gamma subunits.

Step-by-step explanation:

The post-translational lipid modification required for membrane anchoring of heterotrimeric G proteins involves the modification of G-alpha and G-gamma subunits. These modifications involve the addition of lipid molecules such as palmitate or myristate to specific cysteine residues on the subunits. This lipid modification allows the G-alpha and G-gamma subunits to attach to the plasma membrane, while the G-beta subunit remains associated with the G-alpha subunit.