Question

Which of the following is the main criterion that determines whether a protein is processed and presented via the class I MHC pathway in an antigen-presenting cell (APC)?

A. Encoded by a viral gene
B. Present in an acidic vesicular compartment of the APC
C. Present in the cytosol of the APC
D. Internalized into the cell from the extracellular space
E. Small in size

Answer 1

The main criterion for a protein to be processed and presented via the class I MHC pathway in an APC is that it is encoded by a viral gene.

Step-by-step explanation:

The main criterion that determines whether a protein is processed and presented via the class I MHC pathway in an antigen-presenting cell (APC) is that the protein is encoded by a viral gene. Intracellular antigens, such as those produced by viruses, are processed in the cytosol by the proteasome and then brought into the endoplasmic reticulum, where they interact with class I MHC molecules. These antigens are eventually transported to the cell surface for presentation to T cells.