Final answer:
This explanation discusses the activation and response of cytotoxic T-cells through clonal selection. The process involves recognition of an antigen presented with MHC I and interaction of CD8 with the receptor complex. It leads to clonal proliferation and differentiation of activated cytotoxic T-cells into effector or memory cells.
Step-by-step explanation:
Clonal selection is a process in which antigen binds only to T cells that have receptors specific to that antigen. Activation and response of cytotoxic T-cells involve a three-step process similar to helper T cells, but with some key differences. It starts with recognition of an antigen presented with MHC I and interaction of CD8 with the receptor complex. Then, cytokines produced by APCs and cytotoxic T-cells stimulate clonal proliferation and differentiation. Activated cytotoxic T-cells can differentiate into effector cytotoxic T-cells that target pathogens for destruction or memory cells that respond to subsequent exposures.