Question

In T-cell tolerance, negative selection is associated with:

A. presentation of self-antigens to the T cell
B. MHC restriction of the T cell
C. deletion of self-reactive antigen-presenting cells
D. elimination of T-independent antigens

Answer 1

In T-cell tolerance, negative selection is associated with the presentation of self-antigens to the T cell. Negative selection eliminates T cells that bind to self-antigens, preventing an attack on one's own body tissues. This is a crucial process in maintaining immune tolerance.

Step-by-step explanation:

In T-cell tolerance, negative selection is associated with the presentation of self-antigens to the T cell. T-cell tolerance is a process that occurs in the thymus, where T cells that bind to self-antigens are eliminated through apoptosis. This prevents an attack on one's own body tissues. Negative selection plays a crucial role in maintaining immune tolerance.